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When they need to use it, they spike the bag with sterile water, mix it, and it’s ready to inject right then and there.” The artificial blood cell, which is about one-fiftieth the size of a normal red blood cell, is made from purified human hemoglobin proteins that have been coated with a synthetic polymer, Doctor said. Hemoglobin is the component inside red blood cells that carries oxygen throughout the body. It’s estimated that as many as 70 percent of battlefield fatalities are due to shock caused by blood loss rather than life-threatening injuries to vital organs, Doctor said. Additionally, about 20,000 trauma deaths in the United States occur each year due to blood loss prior to arriving at a treatment center. The hunt for an artificial blood substitute has been underway for more than 80 years, but the closest prior attempts have failed in two major ways, Doctor said. Earlier versions could capture oxygen in the lungs, but then would not effectively release the oxygen after traveling out to tissues and organs, he said. http://blogjohnsullivan.techno-rebels.com/2016/08/22/new-ideas-on-elementary-systems-for-interview-body-languageThere also was an unintended reaction between “naked” hemoglobin and nitric oxide, a substance released by the lining of blood vessels that allows the vessels to relax and open up, Doctor noted. “The hemoglobin consumes that molecule and causes a constriction of the blood vessels,” Doctor said. “When they tried to put naked hemoglobin into the bloodstream, it caused heart attacks and strokes.” The synthetic polymer coating of the latest artificial blood cell appears to solve both these problems, Doctor explained. The coating was developed by the study’s lead researcher, Dipanjan Pan, an assistant professor of bioengineering with the University of Illinois at Urbana-Champaign. The surface chemistry of the polymer reacts to the pH level of blood as it travels through the body, Doctor said.
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